The secret of longevity is hidden in our blood

суббота, 26. апреля 2014 - 12:52

Life ends after the body stops producing new blood. And with years of accumulated mutations, which have sinned before - they say that they age and eventually kill - general there is nothing. That is the conclusion reached by scientists from the U.S. and the Netherlands, a large group which analyzed the genome of blood cells of one of the oldest women in the world - Hollandka Hendrick van Andel-Schipper (Hendrikje van Andel-Schipper), who lived 115 years.

Ms. van Andel-Schipper was born in 1890. She died in 2005 in a dream, having a clear mind. An autopsy revealed that in her mind there was no hint typical senile diseases - Alzheimer’s and Parkinson’s. With such a phenomenon doctors pushed first. A few days before his death the old woman turned to the shelter director, in which she lived, saying: “Well here you have, but on top of Mr. said that I must go.” And gone, bequeathing his body to physicians to explore as they please. And publish the results.

Here scientists and shopped long-liver blood with a plan to determine how it - blood - influenced 115 years. The sequencing showed: in healthy blood cells Holstege - in her leukocytes - have accumulated more than 400 mutations. But they focused non-coding regions of the genome. That is not harmful to the body and does not affect life expectancy.

Then it turned out absolutely amazing: the time of death of the old woman it consisted of blood cells produced only two active stem cells - so-called hematopoietic. Although usually blood doing about 1,000 such cells. In other words, the stock of hematopoietic stem cells is exhausted. Blood essentially ceased to be updated. Dolgozhitelnitsa somehow felt sorry for it. And zasobiralas up.

As the scientists explain, a person is born with about 20 thousand stem hematopoietic cells. They are found in bone marrow, have the ability to divide rapidly, turning into all kinds blood cells. Whereby blood and updated. Over the years the ability of stem cells to divide weakens. At each division shortened ends of chromosomes - called telomeres. Until they are barely noticeable. According to one hypothesis, namely the steady shortening of telomeres - Underreplication, scientifically, and ages. To death. It looks like that is - to some extent. At the telomeres Hendrickje blood cells were 17 times shorter than the telomeres of the chromosomes of brain cells. Brain was ok, and the blood - no.

possible to preserve youth and prolong the life of the man, adding he hematopoietic stem cells? Lead researcher Henne Holstege (Henne Holstege) Medical Center Free University of Amsterdam (VU University Medical Center in Amsterdam, the Netherlands) believes that this is not excluded. And as additives suitable stem cells stored at birth.

- These cells - he says - will be free of mutations and their telomeres are full-sized.

According to Henne,Stem cells can be recovered and in the adult human to retain and then add - many years later, when he grows old. Then it again lengthen telomeres. At least a little. But this can be done only with blood.

The study is published in the journal Genome Research called.

Источник:

ru-facts.com

Тэги:

blood