Tel Aviv University scientists develop bionic heart

Heart diseases are the leading cause of death in the West, with heart attacks being most prevalent. "Statistics show that 50% of those who suffered serious heart attacks will die within five years," said Dvir. "What we are trying to do is invent alternative tissues to internal organs in general, and to engineer heart tissue specifically."

The most ambitious development by Dvir and doctoral student Ron Feiner is integrating electronic components into engineered tissue. "The idea is to monitor heart activity online using nano-electronics, and when necessary regulate the engineered tissue activity -- and even to release drugs at the push of a button with the help of special polymers we developed," said Dvir.

"For example, if the tissue signals that there is an inflammation, we can release an anti-inflammatory drug," Dvir said. "If the tissue reports a lack of oxygen, we can release biofactors that attract stem cells to build additional blood vessels, all in real time. The patient is sitting at home and doesn't feel well. The doctor receives a beeper message, logs on and sees the heart's condition. He decides what to do from afar."

Dvir and Feiner, of Tel Aviv University's Biotechnology Department, Materials Science and Engineering Department, and Center for Nanoscience and Nanotechnology, published their findings in the journal Nature Materials on Monday. Dvir is also examining how his proof of concept could apply to the brain and spinal cord to treat neurological conditions.

"This is a breakthrough, to be sure," Dvir said. "But I would not suggest binging on cheeseburgers or quitting sports just yet. The practical realization of the technology may take some time. Meanwhile, a healthy lifestyle is still the best way to keep your heart healthy."

Ilan Gattegno and Israel Hayom Staff